Aging is an eternal topic that human beings cannot avoid. Broadly speaking, aging is the gradual deterioration of cellular biological processes and the accumulation of tissue damage that leads to a decline in organ health and function. This increases the body's susceptibility to age-related diseases, making the organism less responsive to injury and more likely to die.

It can be seen that human aging is a complex physiological process, which is caused by the random changes of molecules, cells and body structure and function caused by the passage of time and the interaction with the environment. Aging is characterized by a progressive decline in physiological functions and tissue homeostasis, leading to an increased incidence of degenerative diseases and death. Anti-aging or delaying the occurrence of aging is also the wish of human beings for thousands of years, but the progress of modern medicine has enabled people to face aging in a more scientific and well-founded way. A few days ago, the top magazine "Nature" published a paper on aging. The researchers found that although senescent cells accumulate everywhere in the body as we age, senescent immune cells are the most dangerous.

The growth state of senescent cells is very special. They stop growing and no longer divide, but they do not enter the death process, so they are also called "zombie cells". These old and immortal cells also secrete a variety of inflammatory molecules that affect surrounding cells. More and more research evidence shows that chronic inflammation and age-related diseases such as atherosclerosis, osteoarthritis, and even diabetes are all related to senescent cells.

Therefore, targeted removal or modification of these cells is the key to the success of reversing aging and prolonging life. The question then becomes-which senescent cells are the first to be eliminated most effectively to reverse aging?

In this study, the research team at the University of Minnesota focused on human immune cells. The researchers transplanted spleen cells from these mice with premature immune system aging into younger mice, resulting in premature aging in young mice, similar to the effect of transplanting spleen cells from ordinary elderly mice. On the contrary, the transplantation of immune cells from young mice to premature aging mice helps to reduce tissue damage and delay aging.

"These data indicate that the aging immune system is the 'cause, 'and that it is the 'effect' to promote the aging of the organism, so to extend a healthy life, the immune system should be the key target," the abstract concluded." This discovery provides an important goal for the development of anti-aging therapies, and in the foreseeable future, in the process of in-depth research on immunosenescence, more mechanisms of the interaction between aging and immunity will be gradually discovered.